Using an immortalized human bronchial epithelial cell line, we showed previously that the transforming growth factor beta-induced (TGFBI) gene was consistently downregulated by six- to sevenfold among radiation-induced tumorigenic human cells when compared with controls. Trans-fection of TGFBI gene into tumor cells resulted in a significant reduction in tumor growth as well as in vitro anchorage independent growth. The observations that TGFBI knock-out animals showed increased spontaneous tumor incidence and chemically induced tumors highlight the suppressive nature of the gene. There is evidence that extranuclear/extracellular targets are important in low-dose radiation response and that the cyclo-oxygenase-2 signaling pathway mediates the process. The involvement of NFκB-dependent cytokines and the resultant inflammatory response works in concert with in modulating radiation-induced bronchial carcinogenesis. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Hei, T. K., Zhao, Y., Zhou, H., & Ivanov, V. (2011). Mechanism of radiation carcinogenesis: Role of the TGFBI gene and the inflammatory signaling cascade. In Advances in Experimental Medicine and Biology (Vol. 720, pp. 163–170). https://doi.org/10.1007/978-1-4614-0254-1_13
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