Chemical and biological investigations of the roots of Sonchus oleraceus L. growing in Egypt

Abstract

Phytochemical study of the roots of Sonchus oleraceus L. (Astraceae) growing in Egypt, afforded loliolide 1 for the first time from the genus Sonchus in addition to 15-O-β-glucopyranosyl-11β,13-dihydrourospermal A 2, ursolic acid 3, lupeol 4, and β-sitosterol-3-O-β-glucopyranoside 5 for the first time from the species. The biological evaluation of the isolated compounds showed cytotoxic activity of 1 and 2 against L5187Y cell line, while compound 2 showed activity against PC33 cell line. In addition to antibacterial activity of compounds 1 and 2 against S. aureus, B. subtilis, E. Coli, and N. gonorrhoea. The structures of the isolated compounds were elucidated using 1D (1H and 13C), 2D (H-H COSY, HMQC and HMBC) NMR and MS spectroscopic data.