Tonsil-derived stem cells as a new source of adult stem cells

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Abstract

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

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Cho, K. A., Lee, H. J., Jeong, H., Kim, M., Jung, S. Y., Park, H. S., … Kim, H. S. (2019, August 1). Tonsil-derived stem cells as a new source of adult stem cells. World Journal of Stem Cells. Baishideng Publishing Group Co. https://doi.org/10.4252/wjsc.v11.i8.506

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