Confirmation of Pharmaceutical Identifiers via DART-TOF-MS

Abstract

A direct analysis in real time ion source coupled with a time-of-flight mass spectrometer (DART-TOF-MS) is a suitable confirmatory technique for the analysis of pharmaceutical preparations, with accompanying reference sources for preparation markings. The DART-TOF-MS instrument allows for simple sample preparation and decreased analysis time, both crucial in a forensic laboratory setting. Differentiation can be made between active drug ingredients with the same molecular weight, such as hydrocodone and codeine, as well as pharmaceutical preparation mixtures, such as oxycodone and acetaminophen, using exact masses of the protonated molecules and fragment peaks compared to a standard.