Animal models to evaluate bacterial biofilm development

Abstract

Medical biofilms have attracted substantial attention especially in the past decade. Animal models are contributing significantly to understand the pathogenesis of medical biofilms. In addition, animal models  are an essential tool in testing the hypothesis generated from clinical observations in patients and preclinical testing of agents showing in vitro antibiofilm effect. Here, we describe three animal models — two non-foreign body Pseudomonas aeruginosa biofilm models and a foreign body Staphylococcus aureus model.