Preparation and anti-tumour activity of some arylbismuth(iii) oxine complexes

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Abstract

New arylbismuth(III) oxinates, PhBi(MeOx)2, (p-MeC6H4)Bi(Ox)2, (p-MeC6H4)Bi(MeOx)2, (p-CIC6H4)Bi(Ox)2, and (p-CIC6H4)Bi(MeOx)2 (Ox- = quinolin-8-olate and MeOx- = 2-methylquinolin-8-olate) have been prepared by reaction of the appropriate diarylbismuth chlorides with Na(Ox) or Na(MeOx) in the presence of 15-crown-5. An X-ray crystallographic study has shown PhBi(MeOx)2 to be a five coordinate monomer with distorted square pyramidal stereochemistry. Chelating MeOx ligands have a cisoid arrangement in the square plane and the phenyl group is apical. The lattice is stabilised by significant Π-Π interactions between centrosymmetric molecules. A range of these complexes has been shown to have high in vitro biological activity (comparable with or better than cisplatin) against L1210 leukaemia, the corresponding cisplatin resistant line, and a human ovarian cell line, SKOV-3. However, initial in vivo testing against a solid mouse plasmacytoma (PC6) and P388 leukaemia has not revealed significant activity.

Figures

  • TABLE 1. Fractional atomic coordinates and Beq (A2)a values for [PhBi(MeOx)2]
  • Figure 1. The molecular structure of PhBi(MeOx)2
  • Figure 2. Unit cell contents for PhBi(MeOx)2
  • TABLE 2. Selected interatomic parameters (,&,, deg.) for PhBi(MeOx)2
  • TABLE 3. In vitro growth inhibition results for bismuth(Ill) compounds against L1210,
  • TABLE 5. In vivo testing results for [KPhBi(Ox)3], dissolved in dimethyl sulfoxide, against P388 leukaemia in mice

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CITATION STYLE

APA

Smith, K. A., Deacon, G. B., Jackson, W. R., Tiekink, E. R. T., Rainone, S., & Webster, L. K. (1998). Preparation and anti-tumour activity of some arylbismuth(iii) oxine complexes. Metal-Based Drugs, 5(5), 295–304. https://doi.org/10.1155/MBD.1998.295

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