Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period

15Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Background: Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. Objective: To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active (DAS28 > 3.2) RA over a period of 12 months. Methods: Thirty-five RA patients (24 (68.6%) females, mean age 53.3 years (SD 13.6)) were investigated clinically by DAS28, tender joint count (TJC) and swollen joint count (SJC) and by FOI in phases 1-3 and PrimaVistaMode (PVM) before therapy change and after 12 months. The FOI activity score (FOIAS) was calculated based on individual joint scores from 0 to 3 in 30 joints per patient, adding up to a sum score (0-90). Results: We found a statistically significant reduction of FOIAS in phase 1 from baseline (median 5.0, IQR 24.96) to follow-up (median 1.0, IQR 4.0) in all patients (p = 0.0045), both in responders and non-responders according to EULAR response criteria by DAS28. Statistically significant reductions over 12 months were found for median DAS28(ESR) 5.61 to 3.31, TJC 7.0 to 1.0, and SJC 5.0 to 1.0 (each p < 0.001). No statistically significant correlations were detected between the FOIAS change in phase 1 and DAS28(ESR), TJC, or SJC. Correlations between the other phases and clinical outcomes were weak to moderate. Conclusion: Reduced early enhancement in FOI phase 1 can be observed in clinically responding and non-responding early RA patients under treatment. Regarding potential marker performance, FOI probably shows a reduction of inflammation more objectively.

References Powered by Scopus

Modified disease activity scores that include twenty‐eight‐joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis

5515Citations
N/AReaders
Get full text

Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis

1474Citations
N/AReaders
Get full text

A Review of indocyanine green fluorescent imaging in surgery

1042Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine

66Citations
N/AReaders
Get full text

Fluorescence optical imaging: Ready for prime time?

16Citations
N/AReaders
Get full text

Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

12Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Glimm, A. M., Sprenger, L. I., Haugen, I. K., Mansmann, U., Hermann, S., Häupl, T., … Ohrndorf, S. (2019). Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period. Arthritis Research and Therapy, 21(1). https://doi.org/10.1186/s13075-019-1989-5

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

71%

Professor / Associate Prof. 1

14%

Researcher 1

14%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

57%

Pharmacology, Toxicology and Pharmaceut... 1

14%

Nursing and Health Professions 1

14%

Agricultural and Biological Sciences 1

14%

Save time finding and organizing research with Mendeley

Sign up for free