Muscle Assessment Using 3D Modeling and Soft Tissue CT Profiling

Abstract

This chapter outlines the methods and applications of X-ray computed tomography (CT) imaging to analyze soft tissue and skeletal muscle density and volume in the context of modern challenges in the field of translational myology. The approaches described here use medical imaging processing techniques and computational methods to quantify muscle morphology, illustrate changes with 3D models, develop numerical profiles specific for each individual, and assess muscle changes due to targeted medical treatment. Applications of these methodologies are summarized in this chapter: (1) subject-specific muscle profiling and association with age, (2) 3D modeling to illustrate and quantify muscle degeneration and its partial reversal via functional electrical stimulation (FES), and (3) muscle profiling to highlight recovery following total hip arthroplasty (THA).