Inhibition of a drug-metabolizing enzyme by the reversible interaction of a drug with the enzyme, thus decreasing the metabolism of another drug, is a major cause of clinically significant drug-drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/ noncompetitive. An in vitro procedure to determine the potential of a drug to be a reversible inhibitor is also provided. Finally, a number of examples of clinically significant drug-drug interactions resulting from reversible inhibition are described. © Springer Science+Business Media, LLC 2014.
CITATION STYLE
Ring, B., Wrighton, S. A., & Mohutsky, M. (2014). Reversible mechanisms of enzyme inhibition and resulting clinical significance. Methods in Molecular Biology, 1113, 37–56. https://doi.org/10.1007/978-1-62703-758-7_4
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