Letting the GENIE out of its bottle: Examining the potential of real-world clinicogenomic dat

Abstract

In this issue, Smyth and colleagues investigate the natural history of AKT1- mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, AKT1 -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as AKT1 -wild-type tumors, but a longer duration of therapy on mTOR inhibitors.