Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines. ©2010 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Debacq-Chainiaux, F., Boilan, E., Le Moutier, J. D., Weemaels, G., & Toussaint, O. (2010). P38MAPK in the senescence of human and murine fibroblasts. Advances in Experimental Medicine and Biology, 694, 126–137. https://doi.org/10.1007/978-1-4419-7002-2_10
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