F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes, which mediate the proteasomal degradation of a diverse range of regulatory proteins. 20 years since the F-box protein family has been discovered, our understanding of substrate-recognition regulation and the roles F-box proteins play in cellular processes has continued to expand. Here, we provide an introduction to the discovery and classification of F-box proteins, the overall structural assembly of SCF complexes, the varied mechanisms by which F-box proteins recognize their substrates, and the role F-box proteins play in diseases and their potentials in targeted therapies.
CITATION STYLE
Nguyen, K. M., & Busino, L. (2020). The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases. In Advances in Experimental Medicine and Biology (Vol. 1217, pp. 111–122). Springer. https://doi.org/10.1007/978-981-15-1025-0_8
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