Thiamine nutritional status and depressive symptoms are inversely associated among older chinese adults

71Citations
Citations of this article
103Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Thiamine has been hypothesized to play an important role in mental health; however, few studies have investigated theassociation between thiamine nutritional status and depression in the general population. Concentrations of free thiamine and its phosphate esters [thiamine monophosphate (TMP) and thiamine diphosphate (TDP)] in erythrocytes were measured by HPLC among 1587 Chinese men and women aged 50-70 y. The presence of depressive symptoms was defined as a Center for Epidemiological Studies Depression Scale score of ≥16. The median erythrocyte concentration (nmol/L) was 3.73 for free thiamine, 3.74 for TMP, and 169 for TDP. The overall prevalence of depressive symptoms was 11.3%. Lower concentrations of all 3 erythrocyte thiamine biomarkers were monotonically associated with a higher prevalence of depressive symptoms: the multivariable adjusted ORs comparing the lowest with the highest quartiles were 2.97 (95% CI = 1.87, 4.72; P-trend < 0.001) for free thiamine, 3.46 (95% CI = 1.99, 6.02; P-trend < 0.001) for TMP, and 1.98 (95% CI = 1.22, 3.21; P-trend = 0.002) forTDP. In conclusion, poorer thiamine nutritional status and higher odds of depressive symptoms were associated among older Chinese adults. This finding should be further investigated in prospective or interventional studies. © 2013 American Society for Nutrition.

Cite

CITATION STYLE

APA

Zhang, G., Ding, H., Chen, H., Ye, X., Li, H., Lin, X., & Ke, Z. (2013). Thiamine nutritional status and depressive symptoms are inversely associated among older chinese adults. Journal of Nutrition, 143(1), 53–58. https://doi.org/10.3945/jn.112.167007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free