Reliability of different Doppler ultrasound quantification methods and devices in the assessment of therapeutic response in arthritis

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Abstract

Objective. To evaluate the metric qualities of power Doppler ultrasound (PDUS) for different quantification methods and devices in the assessment of arthritis during anti-inflammatory treatment Methods. Twenty-four patients with active arthritis and first-time treatment with the TNF-α inhibitor adalimumab underwent sequential clinical, laboratory and US examination at baseline, weeks 2, 6 and 12. 2D and 3D PDUS was performed by two independent investigators. The images and movies were scored from 0 to 3 and the amount of colour pixels and voxels was calculated. In addition, the resistance index of a synovial artery was measured. Thirteen patients were examined with a second US machine. Results. Treatment response was already observed at week 2 with a significant reduction of 2D (P < 0.01) and 3D scores (P < 0.001). A moderate correlation to 28-joint disease activity score was found for 3D voxel count (rs <0.35, P < 0.001). Interobserver agreement was κ or ICC > 0.8 for all methods except the resistance index (ICC = 0.60). Intermachine agreement was κ = 0.57 for 2D PDUS score. Conclusions. The study demonstrates good to excellent interobserver and moderate intermachine reliability of different PDUS assessment methods in a longitudinal open-label study. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

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Albrecht, K., Grob, K., Lange, U., Müller-ladner, U., & Strunk, J. (2008). Reliability of different Doppler ultrasound quantification methods and devices in the assessment of therapeutic response in arthritis. Rheumatology, 47(10), 1521–1526. https://doi.org/10.1093/rheumatology/ken318

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