This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds. © 2007 Elsevier Ltd. All rights reserved.
CITATION STYLE
Hernández, J. C., León, F., Brouard, I., Torres, F., Rubio, S., Quintana, J., … Bermejo, J. (2008). Synthesis of novel spirostanic saponins and their cytotoxic activity. Bioorganic and Medicinal Chemistry, 16(4), 2063–2076. https://doi.org/10.1016/j.bmc.2007.10.089
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