Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-α expression

Abstract

Background: Chronicinflammatorydiseasesareassociatedwithincreasedcardiovascularmortalitydue toacceleratedatherosclerosis. Results: Chronic inflammation in tristetraprolin (TTP)-deficient mice leads to endothelial dysfunction, which is related to enhanced Nox2-dependent reactive oxygen species production but independent from TNF-α. Conclusion: Inflammation-related oxidative stress is an important mediator in inflammation-driven atherogenesis. Significance: In inflammatory diseases oxidative stress seems to be a major cause of cardiovascular events. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.