Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice

Abstract

Aim: An experiment was conducted to study the haemato-biochemical alterations induced by Diclofenac Sodium toxicity. Materials and Methods: 48 Swiss albino mice of either sex, divided uniformly into four different groups. The mice of group I received only deionised water as control while, group II, III and IV were given Diclofenac sodium @ 2.37 mg/kg B.W, 4.75 mg/kg B.W, 9.5 mg/kg B.W orally for 28 days. Results: In dose dependant significant reductions in TEC, Hb, PCV, MCV, MCHC were observed. No significant change was observed in total WBC count in both the sexes. However, relative values of leukocytes indicated relative neutrophilia and relative lymphopenia in higher group. Biochemically dose dependant significant changes were observed for AST, ALT, Total bilirubin, Total protein, Albumin, Globulin, Cholesterol, Urea, Creatinine and Uric acid in male and female animals. Conclusion: The present study indicates hepatobilliary, nephric and gastrointestinal toxicity in albino swiss mice due to Diclofenac Sodium Toxicity.