Neonatal hereditary neutropenia

Abstract

Hereditary neutropenia includes many disorders of distinct origin and variable prognosis, characterized by a reduction of the absolute neutrophil count (ANC) that predisposes patients to bacterial infections, in particular pyogenic infections, such as cutaneous cellulitis, deep abscesses, pneumonia and sepsis [1, 2]. Susceptibility to bacterial infections, even in patients with severe neutropenia, can be quite variable, depending on the underlying etiology. Congenital neutropenia my be associated with extraematopoietic manifestations.