The inheritance of centromere identity

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Abstract

CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.

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Niikura, Y., Kitagawa, R., & Kitagawa, K. (2016). The inheritance of centromere identity. Molecular and Cellular Oncology, 3(4). https://doi.org/10.1080/23723556.2016.1188226

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