Smoking and AMH levels in women with normal reproductive history

Abstract

Purpose: To investigate the effect of age and smoking on the AMH levels in normal cycling healthy women with normal reproductive history. Materials and methods: In 137 women, blood samples were taken on day 3 of a spontaneous cycle. Serum FSH, LH, E2, progesterone and AMH were measured in all blood samples. For the statistical analysis of the data, t test, Pearson's correlation and linear regression analysis were performed. Results: Of 137 women (43%), 59 were smokers. Age was positively correlated with serum FSH and LH levels (r = 0.584, P < 0.001 and r = 0.330, P < 0.001, respectively) and negatively correlated with serum AMH levels (r =-0.882, P < 0.001). There were no significant differences in FSH, LH, E2, progesterone and AMH levels between smokers and non-smokers. Multiple stepwise linear regression analysis showed that in both smokers and non-smokers, age was the most significant determinant of AMH levels (r =-0.889, P < 0.001 and r =-0.944, P < 0.001, respectively), while smoking was not related to AMH levels. Conclusions: Aging significantly decreases AMH levels in women with normal cycles and normal reproductive history, while smoking does not seem to have significant effects on AMH levels. © Springer-Verlag 2010.