Prevalence and susceptibility pattern of bacterial Urinary Tract Infections among pregnant HIV positive women in Gucha sub-county, Kenya.

Abstract

Background: Urinary tract infection is the most frequent in women, and complications with other diseases like HIV/AIDS, and diabetes management are top public health concerns, especially in a resource-limited setting. Objectives: The main aim of this present study was to determine the prevalence of bacterial UTI among HIV and access the ant-microbial susceptibility of the isolated Bacteria uropathogens in HIV-positive pregnant patients in Gucha Sub County District. Materials and Methods: A prospective cross-sectional study carried out at Gucha sub-county District HIV/AIDS clinic. Mid-stream urine samples were collected from consenting 196 females, who were clinically diagnosed with UTI by the attending Physicians. Standard Microbiological methods were used in the isolation and characterization of bacterial uro-pathogens. Clinical Laboratory Standards Institute’s modifications of the Kirby-Bauer disc diffusion technique were adopted. The data were presented as mean ± standard deviation (SD) and compared with student t-test. Results: Out of 200 mid-stream urine samples 35 pure significant bacterial growth (105 colony forming units/ml of urine) were isolated and these included Escherichia coli, 15(43%), Staphylococcus aureus, 7 (20%) S.saprophyticus 5(14%) Enterococci species, 4(11%) and Klebsiella, 4(11%). The uropathogens isolated were more sensitive to Gentamicin, 32(21%) followed with ciprofloxacin, 26(17%), Nitrofurantoin, 20(13%), Erythromycin, 12(12%), and Nalidixic acid, 17(11%) respectively. Conclusion: Escherichia coli were the most dominant bacteria occurring in the pregnant HIV Patients at Gucha Sub County District. Consequently, Gentamycin should be considered a drug of choice for empirical treatment of UTI in pregnant HIV/AIDS females. Keywords: UTI, pregnant women, Antibacterial, HIV, Seropositive females