Clarithromycin monohydrate: A synchrotron X-ray powder study

Abstract

In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C 38H 69NO 13·H 2O, the water molecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hydroxy groups of the 14-membered aglycone ring. The CAM molecules are linked through these hydrogen bonds into chains running parallel to the c axis.