SYNTHETIC NUCLEIC ACID ANALOGS. PREPARATION AND INTERACTION.

Abstract

In order to prepare simply designed nucleic acid models with high functionality, a series of polymeric compounds containing purine and pyrimidine bases as pendant, functional side groups were prepared successfully from their corresponding monomers by either polymerization or polycondensation techniques. As for the functionality of the polymers prepared, specific base-base interactions were studied in detail by measuring UV, NMR and emission spectroscopies. The specific interaction study was particularly made on poly-L-Lysine derivatives having nucleic acid bases in relation to their molecular weight, their conformation in solutions and other properties. From photodimerization study on the model compounds containing thymine bases, intramolecular features of the reaction were elucidated. Owing to the specific properties of the polymers, the studies will find a number of application possibilities, including separation techniques and polymeric drug chemistry. Graft copolymers of nucleic acid bases on polyethyleneimine were also concerned.