Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress

70Citations
Citations of this article
95Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Lipid droplets (LDs) are multi-functional organelles consisting of a neutral lipid core surrounded by a phospholipid monolayer, and exist in organisms ranging from bacteria to humans. Here we study the functions of LDs in the oleaginous bacterium Rhodococcus jostii. We show that these LDs bind to genomic DNA through the major LD protein, MLDS, which increases survival rate of the bacterial cells under nutritional and genotoxic stress. MLDS expression is regulated by a transcriptional regulator, MLDSR, that binds to the operator and promoter of the operon encoding both proteins. LDs sequester MLDSR, controlling its availability for transcriptional regulation. Our findings support the idea that bacterial LDs can regulate nucleic acid function and facilitate bacterial survival under stress.

References Powered by Scopus

MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods

36420Citations
N/AReaders
Get full text

Clustal W and Clustal X version 2.0

24652Citations
N/AReaders
Get full text

The I-TASSER suite: Protein structure and function prediction

4495Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Lipid droplet functions beyond energy storage

419Citations
N/AReaders
Get full text

Plant lipid droplets and their associated proteins: Potential for rapid advances

200Citations
N/AReaders
Get full text

Critical steps in carbon metabolism affecting lipid accumulation and their regulation in oleaginous microorganisms

152Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zhang, C., Yang, L., Ding, Y., Wang, Y., Lan, L., Ma, Q., … Liu, P. (2017). Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress. Nature Communications, 8. https://doi.org/10.1038/ncomms15979

Readers over time

‘17‘18‘19‘20‘21‘22‘23‘24‘2506121824

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 39

66%

Researcher 9

15%

Professor / Associate Prof. 8

14%

Lecturer / Post doc 3

5%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 36

60%

Agricultural and Biological Sciences 15

25%

Immunology and Microbiology 6

10%

Chemistry 3

5%

Article Metrics

Tooltip
Mentions
Blog Mentions: 2
Social Media
Shares, Likes & Comments: 17

Save time finding and organizing research with Mendeley

Sign up for free
0