Serological methods such as the enzyme-linked immunosorbent assay (ELISA) and virus neutralization test are fundamental tools used in diagnosis, seroepidemiological studies of filovirus transmission/prevalence, and the evaluation of vaccine immunogenicity and potential therapeutic antibodies. Filoviruses have a single transmembrane glycoprotein (GP), which is the only known target of neutralizing antibodies. Here we describe serological methods to quantify filovirus GP-specific antibodies.
CITATION STYLE
Furuyama, W., Miyamoto, H., Yoshida, R., & Takada, A. (2017). Quantification of filovirus glycoprotein-specific antibodies. In Methods in Molecular Biology (Vol. 1628, pp. 309–320). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7116-9_25
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