Screening of biologically active monosaccharides: Growth inhibitory effects of d-allose, d-talose, and l-idose against the nematode caenorhabditis elegans

Abstract

We compared the growth inhibitory effects of all aldohexose stereoisomers against the model animal Caenorhabditis elegans. Among the tested compounds, the rare sugars D-allose (D-All), D-talose (D-Tal), and L-idose (L-Ido) showed considerable growth inhibition under both monoxenic and axenic culture conditions. 6-Deoxy-D-All had no effect on growth, which suggests that C6-phosphorylation by hexokinase is essential for inhibition by D-All.