Comparative Study of Liver Function and Rh Blood Group between both Physiological and Pathological Neonatal Jaundice

Abstract

Jaundice occurs in most newborn due to increase bilirubin concentration. Jaundice is detected at first week after birth in approximately 60% of full-term neonates. A high level of bilirubin is neurotoxic and may cause neonatal kernicterus, auditory neuropathy or death. The article aims to compare the Rh group compatibility, serum bilirubin (total and direct), serum albumin and several liver enzymes (alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase) between physiological and pathological neonatal jaundice. The study was conducted for one hundred neonates with jaundice divided into two groups, group one includes fifty newborns with physiological jaundice, Group two includes fifty newborns with pathological jaundice. Blood samples were taken from each patient, used to determine the Rh group, serum bilirubin (total and direct, liver enzymes and albumin levels. In the present study, it was found that Rh compatibility show a significant relationship between newborns with physiological and pathological jaundice (p>0.05). Serum bilirubin (total and direct), serum albumin concentration and the liver enzymes were significantly higher when compare between newborns and pathological jaundice with newborns of physiological jaundice (p>0.05). These findings demonstrate that the newborns with pathological jaundice have significantly higher levels of the studied parameters (Serum bilirubin, albumin and several liver enzymes) in comparison with those with physiological jaundice.