This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing confirmed achievement of therapeutically relevant drug levels that matched or exceeded those for oral dosing, with a dramatic reduction in undesired emetic responses. Intranasal drug delivery is an effective option for the treatment of Alzheimer's disease and other central nervous system disorders. © 2008 Costantino et al; licensee BioMed Central Ltd.
CITATION STYLE
Costantino, H. R., Leonard, A. K., Brandt, G., Johnson, P. H., & Quay, S. C. (2008). Intranasal administration of acetylcholinesterase inhibitors. In BMC Neuroscience (Vol. 9). BioMed Central Ltd. https://doi.org/10.1186/1471-2202-9-s3-s6
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