Luteolin

Abstract

Luteolin is extracted from Honeysuckle (Lonicera japonica Thunb), which is the most important flavone in Honeysuckle. Plants rich in luteolin have been used for treating various diseases such as hypertension, inflammatory disorders, and cancer. The biological effects of luteolin could be functionally related to each other. For instance, the anti-inflammatory activity may be linked to its anticancer property. Luteolin can selectively inhibit the fatty acid synthase activity in prostate cancer and breast cancer cells, which is related to the inhibitory effect of luteolin on tumor cell growth and apoptosis. Luteolin can enhance the transfer of synapses in the hippocampus dentate gyrus, causing long-term potentiation. Most studies on luteolin were carried out in vitro, lacking in vivo experimental results. Therefore, it is necessary to further explore the pharmacological activity and pharmacokinetics of luteolin in vivo, so as to provide a solid theoretical basis for its clinical application.