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A click chemistry approach towards nucleic acid major groove functionalization

Nucleic acids symposium series (2004) (2008) (52) 149-150
DOI: 10.1093/nass/nrn076
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Abstract

A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is presented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.

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Andersen, N. K., Spácilová, L., Jensen, M. D., Kocalka, P., Jensen, F., & Nielsen, P. (2008). A click chemistry approach towards nucleic acid major groove functionalization. Nucleic Acids Symposium Series (2004), (52), 149–150. https://doi.org/10.1093/nass/nrn076

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