Background: Limited information is available on the association between vitamin B-12 status and intake from different dietary sources. Objective: We investigated the relation of dietary intake of different food items with plasma vitamin B-12 concentrations in the general population. Design: A cross-sectional, population-based study of 5937 subjects in 2 age groups (47-49 and 71-74 y) from the Hordaland Homocysteine Study in Norway was conducted by using a food-frequency questionnaire and measurements of plasma vitamin B-12 concentrations. Results: A significant difference in plasma vitamin B-12 concentrations was observed with increasing total vitamin B-12 intake. A plateau was reached at an intake of ≈10 μg/d. Plasma vitamin B-12 was associated with intakes of increasing amounts of vitamin B-12 from dairy products or fish (P for trend <0.001 for both) but not with intakes of vitamin B-12 from meat or eggs. For the same content of vitamin B-12, intake from dairy products led to the greatest increase in plasma vitamin B-12. Total intake of vitamin B-12, particularly from milk and fish, decreased the risk of vitamin B-12 concentrations <200 pmol/L and impaired vitamin B-12 function (vitamin B-12 <200 pmol/L and methylmalonic acid >0.27 μmol/L) in the total group and in 71-74-y-old subjects. Conclusions: Dietary intake of dairy products and fish are significant contributors to plasma vitamin B-12 and may improve plasma vitamin B-12 status. Vitamin B-12 appears to be more bioavailable from dairy products; guidelines for improving vitamin B-12 status should take this into consideration. © 2009 American Society for Nutrition.
CITATION STYLE
Vogiatzoglou, A., Smith, A. D., Nurk, E., Berstad, P., Drevon, C. A., Ueland, P. M., … Refsum, H. (2009). Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: The Hordaland Homocysteine Study. American Journal of Clinical Nutrition, 89(4), 1078–1087. https://doi.org/10.3945/ajcn.2008.26598
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