Pharmacotherapy of Peptic Ulcer Disease and Latest Research

Abstract

Peptic ulcers have unquestionably been a disease of the twentieth century. Epidemiological data for this disease and its complications have shown striking variation in incidence and prevalence. Various drugs have been used to treat peptic ulcer disease like proton-pump inhibitors, histamine (H2) receptor antagonists, prostaglandin analogues and sucralfate. Because these drugs are complex, expensive and toxic, efforts have been constantly made to find a suitable, palliative and curative agent for the treatment of peptic ulcer disease from natural products of plant and animal origin. Recently, antioxidants are being used to treat peptic ulcer disease. Antioxidants help in scavenging the free radicals and controlling the oxida-tive stress responsible for the progression of peptic ulcer.