The solution structure of the invasive tip complex from Afa/Dr fibrils

41Citations
Citations of this article
27Readers
Mendeley users who have this article in their library.

Abstract

Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition. © 2006 The Authors.

Cite

CITATION STYLE

APA

Cota, E., Jones, C., Simpson, P., Altroff, H., Anderson, K. L., Du Merle, L., … Matthews, S. (2006). The solution structure of the invasive tip complex from Afa/Dr fibrils. Molecular Microbiology, 62(2), 356–366. https://doi.org/10.1111/j.1365-2958.2006.05375.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free