The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes

Abstract

Background: Staphylococcus aureus LcpABC attach wall teichoic acids (WTA) to peptidoglycan. Results: S. aureus capsular polysaccharide (CP5) is linked to peptidoglycan in a manner requiring lcpABC genes. Conclusion: Unlike WTA, CP5 attachment is mediated preferentially by LcpC. Significance: LCP proteins display substrate preferences for the transfer of undecaprenyl-bound polymers to peptidoglycan. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.