Homeotic miRNAs: From development to pathologies

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Abstract

Hox genes are key elements for anterio-posterior morphogenesis. Hox genes are tightly regulated at the transcriptional level. This level of regulation, however, is by far not unique, and non-coding RNAs, and in particular micro-RNAs, provide an important supplementary level of regulation. This review recapitulates what is known about Hox-related microRNAs, describes a technique that can be used to address miRNA function and attempts to speculate on the function of regulation by miRNAs and how it may impact on medicine.

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Ameyar-Zazoua, M., Naguibneva, I., Pritchard, L., & Harel-Bellan, A. (2008). Homeotic miRNAs: From development to pathologies. In Current Perspectives in microRNAs (miRNA) (pp. 119–127). Springer Netherlands. https://doi.org/10.1007/978-1-4020-8533-8_7

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