A model of stroke and vascular injury in the brain

Abstract

Recent clinical trials have revealed high rates of delayed restenosis and hemorrhage in angioplasty and stenting in intracranial atherosclerotic diseases, but the causes of this are still unclear. These unfavorable results may be caused by unique properties of intracranial internal carotid arteries (IICAs) such as lack of an external elastic lamina and presence of surrounding cerebrospinal fluid. Clarification of the mechanism of remodeling after vascular injury to IICAs using injury models is needed, although several studies have clarified the pathophysiology and molecular mechanisms involved in the remodeling process after injury to extracranial arteries. In this section, a detailed protocol for an IICA injury (IICAI) model is summarized. We also review the intraluminal suture middle cerebral artery occlusion (MCAo) model in mice, which causes cerebral infarction in the area of the middle cerebral artery region, because the IICAI model is a modification of the intraluminal suture MCAo model.