Immunogenetics of type 1 diabetes mellitus - from fundamental ideas to medical practice

Abstract

TTie review ofstudies of Russian researchers on theoretical and practical aspects of genetic predisposition to type 1 diabetes associated with immunity: HLA and not HLA genes. Most important for practical public health outcomes are evidence that HLA-genetic predisposition to type 1 diabetes is ssociated with the DRBl-genotype, consisting entirely of variants DRBl-genes associated with the development of TID. It was also established that CTLA4gene has an independent predictive value for TID.