This paper presents a new green protocol for Knoevenagel condensations of aldehydes and compounds with an active methylene group in a binary mixture of ethanol/water (3:7, v/v). This medium favored the uncatalyzed Knoevenagel reactions and easy workup products can be obtained by precipitation in this medium and showed good isolated yields (55-100%) in short reaction times (1-60 min).
CITATION STYLE
Ferreira, J. M. G. O., De Resende Filho, J. B. M., Batista, P. K., Teotonio, E. E. S., & Vale, J. A. (2018). Rapid and efficient uncatalyzed knoevenagel condensations from binary mixture of ethanol and water. Journal of the Brazilian Chemical Society, 29(7), 1382–1387. https://doi.org/10.21577/0103-5053.20170240
Mendeley helps you to discover research relevant for your work.