Since the cloning of the gene responsible for Duchenne and Becker muscular dystrophy two decades ago, a number of other genes have been associated with various forms of muscular dystrophy. The protein products of these genes display a diversity of cellular localizations and functions, suggesting a complex pathophysiology within this class of disorders. Two recently identified functions of selected proteins include membrane repair and glycosylation, providing important insights into the disease process. A definitive cure remains elusive, but supportive therapies have become increasingly sophisticated, improving the quality of life and lengthening the life expectancy for many affected individuals. © 2006 Humana Press Inc.
CITATION STYLE
Kang, P. B., & Kunkel, L. M. (2006). Muscular dystrophies: Mechanisms. In Principles of Molecular Medicine (pp. 693–699). Humana Press. https://doi.org/10.1007/978-1-59259-963-9_70
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