Valosin-containing protein promotes metastasis of osteosarcoma through autophagy induction and anoikis inhibition via the ERK/NF-κβ/beclin-1 signaling pathway

11Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Valosin-containing protein (VCP) promotes the development of metastasis in osteosarcoma (OS) via the PI3K/Akt signaling pathway. However, inhibition of the PI3K/Akt pathway does not completely reverse VCP-mediated invasion and migration of OS, suggesting that VCP-mediated OS invasion and migration involves additional mechanisms. In the present study, a positive correlation between the expression of VCP and cell autophagy was observed among OS tissues. Inhibiting VCP may decrease the survival of malignant cells; however, an autophagy stimulator may compensate for VCP inhibition and promote malignant cell survival. Altering the level of autophagy did not affect cell invasiveness or migration. ERK, NF-κβ and beclin-1 protein expression levels were markedly decreased following VCP inhibition. These findings indicated that VCP may induce autophagy and enhance anoikis resistance without affecting cell invasiveness or migration. Via anoikis resistance, VCP may promote metastasis in OS. Therefore, targeting of the ERK/NF-κβ/beclin-1 signaling pathway may be an effective therapeutic strategy for the management of OS.

References Powered by Scopus

Metastasis: From dissemination to organ-specific colonization

2165Citations
N/AReaders
Get full text

The microenvironment of the tumour - Host interface

2102Citations
N/AReaders
Get full text

Tumor metastasis: Mechanistic insights and clinical challenges

1853Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The dual role of autophagy in cancer development and a therapeutic strategy for cancer by targeting autophagy

115Citations
N/AReaders
Get full text

Valosin-containing protein (VCP)/p97: A prognostic biomarker and therapeutic target in cancer

41Citations
N/AReaders
Get full text

Autophagy and its role in osteosarcoma

15Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Hua Long, X., Fei Zhou, Y., Lan, M., Hu Huang, S., Li Liu, Z., & Shu, Y. (2019). Valosin-containing protein promotes metastasis of osteosarcoma through autophagy induction and anoikis inhibition via the ERK/NF-κβ/beclin-1 signaling pathway. Oncology Letters, 18(4), 3823–3829. https://doi.org/10.3892/ol.2019.10716

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

88%

Researcher 1

13%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 4

67%

Nursing and Health Professions 1

17%

Neuroscience 1

17%

Save time finding and organizing research with Mendeley

Sign up for free