Loss of Gadd45b accelerates BCR-ABL-driven CML

11Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Gadd45b is a member of Gadd45 stress sensor protein family that also includes Gadd45a and Gadd45g. To investigate the effect of Gadd45b in bcr-abl oncogene driven chronic myeloid leukemia (CML) development, syngeneic wild type lethally irradiated mice were reconstituted with either wild type or Gadd45b null myeloid progenitors transduced with a retroviral vector expressing BCR-ABL. Loss of Gadd45b was observed to accelerate BCR-ABL driven CML development with shortened median mouse survival time. BCR-ABL Gadd45b deficient CML progenitors exhibited increased proliferation and decreased apoptosis, associated with hyper-activation of c-Jun NH2- terminal kinase and Stat5. These results provide novel evidence that gadd45b, like gadd45a, functions as a suppressor of BCR-ABL driven leukemia, albeit via a different mechanism.

References Powered by Scopus

A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

3605Citations
N/AReaders
Get full text

Induction of chronic myelogenous leukemia in mice by the P210 <sup>bcr/abl</sup> gene of the Philadelphia chromosome

2046Citations
N/AReaders
Get full text

Tyrosine kinase activity and transformation potency of bcr-abl oncogene products

1177Citations
N/AReaders
Get full text

Cited by Powered by Scopus

GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis

36Citations
N/AReaders
Get full text

GADD45g acts as a novel tumor suppressor, and its activation suggests new combination regimens for the treatment of AML

20Citations
N/AReaders
Get full text

Roles for GADD45 in Development and Cancer

19Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Sha, X., Hoffman, B., & Liebermann, D. A. (2018). Loss of Gadd45b accelerates BCR-ABL-driven CML. Oncotarget, 9(70), 33360–33367. https://doi.org/10.18632/oncotarget.26076

Readers over time

‘19‘20‘21‘22‘23‘2402468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

75%

Professor / Associate Prof. 1

25%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 5

83%

Medicine and Dentistry 1

17%

Save time finding and organizing research with Mendeley

Sign up for free
0