Background: Low-dose metronomic (LDM) chemotherapy is a novel approach that involves frequent administration of a low dose of chemotherapeutic agent without a long interval. Purpose: The aim of this clinical pilot study was to evaluate the toxicity and efficacy of LDM chemotherapy with weekly low-dose docetaxel for previously treated non-small cell lung cancer (NSCLC). Patients and methods: The enrolled patients received 15 mg/m2 of docetaxel intravenously on a weekly basis without any interval. Results: Twenty-seven patients were enrolled in the study; 20 were men, and seven were women. The median age was 62 years (range: 32-75). Eleven patients were stage IIIB, and 16 were stage IV. The Eastern Cooperative Oncology Group performance status was 0 or 1. There was no severe hematological adverse effect; importantly, there was no neutropenia or thrombocytopenia. The objective response rate was 7.4% and the disease control rate was 51.9%. The median survival time was 16.4 months (95% CI: 5.7-36.4). Conclusion: Our preliminary results indicate that our metronomic regimen was well tolerated and active in patients with previously treated NSCLC. Thus, further investigation of this LDM regimen is warranted. © 2012 Yokoi et al, publisher and licensee Dove Medical Press Ltd.
CITATION STYLE
Yokoi, T., Tamaki, T., Shimizu, T., & Nomura, S. (2012). A pilot study of a metronomic chemotherapy previously treated non-small cell lung cancer previously treated non-small cell lung cancer. Lung Cancer: Targets and Therapy, 3, 15–20. https://doi.org/10.2147/LCTT.S30937
Mendeley helps you to discover research relevant for your work.