Management of Erythema Multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Abstract

Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune-mediated disorders with distinct pathogenesis, clinical manifestations and prognosis. The management of these conditions is controversial due to a lack of well-designed randomised controlled trials. Removal of the offending agent, in-hospital management and regular surveillance for superimposed infection are basic requirements in the management of EM, SJS and TEN. The evidence supporting corticosteroids, immunosuppressants, antibiotics and biologic agents is lacking.