Some historical background is given for appreciating the impact of the empirical construct known as the cellular protein-protein interactome, which is a seemingly de novo entity that has arisen of late within the context of postgenomic systems biology. The approach here builds on a generalized principle of "fuzziness" in protein behavior, proposed by Tompa and Fuxreiter. 1 Recent controversies in the analysis and interpretation of the interactome studies are rationalized historically under the auspices of this concept. There is an extensive literature on protein-protein interactions, dating to the mid-1900s, which may help clarify the "fuzziness" in the interactome picture and, also, provide a basis for understanding the physiological importance of protein-protein interactions in vivo. © 2012 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Welch, G. R. (2012). “fuzziness” in the celular interactome: A historical perspective. Advances in Experimental Medicine and Biology, 725, 184–190. https://doi.org/10.1007/978-1-4614-0659-4_11
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