Heat and mass transfer in the hyperthermia cancer treatment by magnetic nanoparticles

Abstract

In this study, a more precise and cost-effective method is used for studying the drug delivery and distribution of magnetic nanoparticles in fluid hyperthermia cancer treatment, and numerical methods are employed to determine the effect of blood circulation on heat transfer and estimate the success of cancer treatment. A combination of numerical, analytical, and experimental researches is being conducted, which illustrates the essential role of numerical methods in medical and biomedical science. Magnetic NanoParticles’ distribution and effects of infusion rate on the treatment are also discussed by considering the real distribution of MNPs. To increase accuracy and reduce costs in the in-vitro section, direct cutting and image processing methods are used instead of MRI. Based on the results of this section, with a tenfold increase in the infusion rate (4 μl/min to 40 μl/min), the penetration depth increases by 1 mm, which represents a nearly 17 percent increase. Concentrations of MNPs also decrease significantly at higher infusion rates. The simulations of heat transfer reveal that maximum temperatures occur at the lowest infusion rate (1.25 μl/min), and blood flow also has a significant effect on heat transfer. With an increase in the infusion rate, necrosis tissue recedes from the tumor center and approaches the border between the tumor and healthy tissue. Results also show that, in lower MNPs’ concentrations, higher infusion rates result in better treatment even though minimum infusion rates are suggested to be the best rates to facilitate distribution and treatment.