The authors describe a microarray system for disease diagnosis based on antibody-antigen interactions. Either biotinylated antibodies or antigens are coupled via streptavidin linkers onto a gold surface. This platform has been used to establish recombinant antibody-antigen interactions and to detect specific IgM antibodies in sera of patients suspected of Lyme borreliosis. Therefore, this microarray system can be adapted for further applications.
CITATION STYLE
Pavlickova, P., & Hug, H. (2004). A streptavidin-biotin-based microarray platform for immunoassays. Methods in Molecular Biology (Clifton, N.J.), 264, 73–83. https://doi.org/10.1385/1-59259-759-9:073
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