HTLV-1 infection of myeloid cells: From transmission to immune alterations

20Citations
Citations of this article
62Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which represent the main reservoir for HTLV-1, have been the main focus of studies aimed at understanding viral transmission and disease progression. However, other cell types such as myeloid cells are also target of HTLV-1 infection and display functional alterations as a consequence. In this work, we review the current investigations that shed light on infection, transmission and functional alterations subsequent to HTLV-1 infection of the different myeloid cells types, and we highlight the lack of knowledge in this regard.

Author supplied keywords

References Powered by Scopus

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

2590Citations
N/AReaders
Get full text

HTLV-I ASSOCIATED MYELOPATHY, A NEW CLINICAL ENTITY

2069Citations
N/AReaders
Get full text

Adult T-cell leukemia: Clinical and hematologic features of 16 cases

1917Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application

69Citations
N/AReaders
Get full text

HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread

31Citations
N/AReaders
Get full text

Htlv-1 infection and pathogenesis: New insights from cellular and animal models

24Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Rocamonde, B., Carcone, A., Mahieux, R., & Dutartre, H. (2019, December 23). HTLV-1 infection of myeloid cells: From transmission to immune alterations. Retrovirology. BioMed Central Ltd. https://doi.org/10.1186/s12977-019-0506-x

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 12

55%

Researcher 7

32%

Professor / Associate Prof. 3

14%

Readers' Discipline

Tooltip

Immunology and Microbiology 10

36%

Biochemistry, Genetics and Molecular Bi... 7

25%

Medicine and Dentistry 6

21%

Agricultural and Biological Sciences 5

18%

Save time finding and organizing research with Mendeley

Sign up for free