HTLV-1 infection of myeloid cells: From transmission to immune alterations

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Abstract

Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which represent the main reservoir for HTLV-1, have been the main focus of studies aimed at understanding viral transmission and disease progression. However, other cell types such as myeloid cells are also target of HTLV-1 infection and display functional alterations as a consequence. In this work, we review the current investigations that shed light on infection, transmission and functional alterations subsequent to HTLV-1 infection of the different myeloid cells types, and we highlight the lack of knowledge in this regard.

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Rocamonde, B., Carcone, A., Mahieux, R., & Dutartre, H. (2019, December 23). HTLV-1 infection of myeloid cells: From transmission to immune alterations. Retrovirology. BioMed Central Ltd. https://doi.org/10.1186/s12977-019-0506-x

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