Laboratory models for central nervous system tumor stem cell research

Abstract

Central nervous system (CNS) tumors are complex organ systems comprising of a neoplastic component with associated vasculature, infl ammatory cells, and reactive cellular and extracellular components. Research has identifi ed a subset of cells in CNS tumors that portray defi ning properties of neural stem cells, namely, that of self-renewal and multi-potency. Growing evidence suggests that these tumor stem cells (TSC) play an important role in the maintenance and growth of the tumor. Furthermore, these cells have also been shown to be refractory to conventional therapy and may be crucial for tumor recurrence and metastasis. Current investigations are focusing on isolating these TSC from CNS tumors to investigate their unique biological processes. This understanding will help identify and develop more effective and comprehensive treatment strategies. This chapter provides an overview of some of the most commonly used laboratory models for CNSTSC research.