Re current acute pancreatitis prevention by the elimination of alcohol and ciga r ette smoking (REAPPEAR): Protocol of a randomised controlled trial and a cohort study

12Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.

Abstract

Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/EÜIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals. Trial registration number NCT04647097

References Powered by Scopus

Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption‐II

10657Citations
N/AReaders
Get full text

The Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire

9196Citations
N/AReaders
Get full text

Classification of acute pancreatitis - 2012: Revision of the Atlanta classification and definitions by international consensus

4995Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Malondialdehyde-Acetaldehyde Extracellular Matrix Protein Adducts Attenuate Unfolded Protein Response During Alcohol and Smoking–Induced Pancreatitis

17Citations
N/AReaders
Get full text

Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage

17Citations
N/AReaders
Get full text

Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study

15Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ocskay, K., Juhász, M. F., Farkas, N., Zádori, N., Szakó, L., Szakács, Z., … Hegyi, P. (2022). Re current acute pancreatitis prevention by the elimination of alcohol and ciga r ette smoking (REAPPEAR): Protocol of a randomised controlled trial and a cohort study. BMJ Open, 12(1). https://doi.org/10.1136/bmjopen-2021-050821

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

50%

Researcher 6

43%

Lecturer / Post doc 1

7%

Readers' Discipline

Tooltip

Medicine and Dentistry 6

50%

Nursing and Health Professions 3

25%

Psychology 2

17%

Neuroscience 1

8%

Save time finding and organizing research with Mendeley

Sign up for free