The single- and repeated-dose pharmacokinetics of sabeluzole have been determined in six elderly patients with [senile] dementia of the Alzheimer type. After a single oral dose of 10 mg sabeluzole, the peak plasma concentration was attained at 1 to 4 h; it averaged 42 ng·ml-1. On repeated dosing (10 mg b. d.), steady-state was virtually attained after 3 days of treatment. Steadystate mean trough and peak plasma concentrations fluctuated between 53 and 94 ng·ml-1. The mean terminal half-life after a single dose and at steady-state was of the order of 33 h. Sabeluzole was well tolerated and at the end of treatment, no systematic changes in blood haematology, biochemistry or urinalysis were seen. © 1992 Springer-Verlag.
CITATION STYLE
De Deyn, P. P., Van de Velde, V., Verslegers, W., Saerens, J., Pickut, B. A., Clincke, B., … Van Peer, A. (1992). Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients. European Journal of Clinical Pharmacology, 43(6), 661–662. https://doi.org/10.1007/BF02284969
Mendeley helps you to discover research relevant for your work.